' 
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
USERS' SCORE
Good
Based on 10 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
7
Vitamin C's uncertain heart benefits
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.
Relevant discussion on vitamin C
We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
Focus on vitamin C effectiveness
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
Relevant to cardiac care research
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
Most Useful Reviews
8.8
Protects against heart disease
Grape seed extract possesses antioxidant properties superior to other known antioxidants, including vitamins C and E. It protects against heart disease and cancer, enhances vessel condition, safeguards brain cells, and promotes overall vascular health. I always keep this product on hand and use it as a preventive measure for varicose veins. If my review has piqued your interest, please click "YES".
Read More
9.5
Increases circulation
I have peripheral artery disease due to years of smoking and a sedentary lifestyle. My job involves long hours of sitting, leading to a burning sensation in my thighs. This product has alleviated those symptoms by enhancing my circulation.
Read More
7.5
Supports heart health
Grape seed extract provides various health benefits: it lowers bad cholesterol, prevents cardiovascular disease, and helps maintain endothelial cell function. It's beneficial for diverse groups, including those susceptible to heart disease, high cholesterol, or varicose veins. Please like my comment if you found it helpful.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.8
- All Researches
9
Vitamin C's potential in heart health
Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats.
Combination treatment assessed
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
Read More
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
Focus on vitamin C effectiveness
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Combined antioxidants may benefit heart
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
Limited isolated effect of vitamin C
We explored the potential of a combined antioxidant therapy that includes vitamin C to address myocardial reperfusion injury—a condition that can worsen heart damage after blood flow is restored following ischemia. In a Phase 1 clinical trial involving healthy participants, we tested whether this therapy could be safely administered while also examining the effects on oxidative stress, a key factor in heart injury.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Read More
8
BM-164 shows heart-protective effects
Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts.
Vitamin C's isolated effects unclear
We explored the effects of a novel water-soluble derivative of ascorbic acid, known as BM-164, on heart health under conditions of ischemia and reperfusion in rat hearts. This study aimed to combine the cardiovascular benefits of hydrogen sulfide (HS) with the antioxidant properties of ascorbic acid.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Protects against heart disease
Grape seed extract possesses antioxidant properties superior to other known antioxidants, including vitamins C and E. It protects against heart disease and cancer, enhances vessel condition, safeguards brain cells, and promotes overall vascular health. I always keep this product on hand and use it as a preventive measure for varicose veins. If my review has piqued your interest, please click "YES".
Read More
9.5
Increases circulation
I have peripheral artery disease due to years of smoking and a sedentary lifestyle. My job involves long hours of sitting, leading to a burning sensation in my thighs. This product has alleviated those symptoms by enhancing my circulation.
7.5
Supports heart health
Grape seed extract provides various health benefits: it lowers bad cholesterol, prevents cardiovascular disease, and helps maintain endothelial cell function. It's beneficial for diverse groups, including those susceptible to heart disease, high cholesterol, or varicose veins. Please like my comment if you found it helpful.
Read More
9.5
Supports heart and blood
The grape seed extract is excellent for blood and heart health due to its antioxidant properties. With a serving size of one capsule a day, a package lasts three months. The capsules are small and easy to swallow without any smell or taste.
9.5
Improves cholesterol levels
NOW Foods grape seed extract is an exceptional supplement for heart health. After years of taking it, my HDL cholesterol levels are fantastic. This extract effectively neutralises harmful radicals, enhancing overall health. Great product at a reasonable price with high-quality ingredients.
Read More
