5/24/2025
Last update
5/24/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
9
We aimed to explore how grape seed extract can protect the heart from damage caused by doxorubicin, a chemotherapy drug known for its harmful effects on the heart. In a study with 28 male rats, we compared different treatment groups, including those receiving doxorubicin alone and those treated with grape seed extract alongside it.
Our results showed that rats given grape seed extract experienced less heart damage, as indicated by lower levels of injury markers and oxidative stress in their blood and tissue samples. This suggests grape seed extract may potentially help safeguard the heart in chemotherapy settings.
Our results showed that rats given grape seed extract experienced less heart damage, as indicated by lower levels of injury markers and oxidative stress in their blood and tissue samples. This suggests grape seed extract may potentially help safeguard the heart in chemotherapy settings.
Read More
9
We investigated the impact of grape seed proanthocyanidin extract (GSPE) on heart damage caused by cyclosporine A (CsA), an immunosuppressive drug known for its cardiotoxic effects. In a study involving 24 rats, we measured various markers of oxidative damage after treatment with CsA.
Results showed that while CsA increased oxidative damage, the addition of GSPE significantly reduced this damage and improved overall heart health. Notably, GSPE's antioxidant and antiapoptotic properties were found to play a critical role in protecting heart tissue from CsA-induced harm.
Results showed that while CsA increased oxidative damage, the addition of GSPE significantly reduced this damage and improved overall heart health. Notably, GSPE's antioxidant and antiapoptotic properties were found to play a critical role in protecting heart tissue from CsA-induced harm.
Read More
8
We explored how grape seed extract (GSE) might help recover heart cells in a rat model of heart damage caused by isoproterenol. In our study, we assigned 70 rats into four groups, some receiving GSE, while others were induced with heart issues.
Our findings revealed that GSE significantly improved the number of certain supportive heart cells and blood vessels after heart injury. While there was an overall increase in cardiac telocytes with GSE, the increase wasn't substantial enough to draw definitive conclusions about its effectiveness in treating heart disease.
Our findings revealed that GSE significantly improved the number of certain supportive heart cells and blood vessels after heart injury. While there was an overall increase in cardiac telocytes with GSE, the increase wasn't substantial enough to draw definitive conclusions about its effectiveness in treating heart disease.
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Most Useful Reviews
7.5
Protects against heart disease
52 people found this helpful
Grape seed extract possesses antioxidant properties superior to other known antioxidants, including vitamins C and E. It protects against heart disease and cancer, enhances vessel condition, safeguards brain cells, and promotes overall vascular health. I always keep this product on hand and use it as a preventive measure for varicose veins. If my review has piqued your interest, please click "YES".
Read More
9
Increases circulation
6 people found this helpful
I have peripheral artery disease due to years of smoking and a sedentary lifestyle. My job involves long hours of sitting, leading to a burning sensation in my thighs. This product has alleviated those symptoms by enhancing my circulation.
Read More
7.5
Supports heart health
3 people found this helpful
Grape seed extract provides various health benefits: it lowers bad cholesterol, prevents cardiovascular disease, and helps maintain endothelial cell function. It's beneficial for diverse groups, including those susceptible to heart disease, high cholesterol, or varicose veins. Please like my comment if you found it helpful.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8
- All Researches
9
We aimed to explore how grape seed extract can protect the heart from damage caused by doxorubicin, a chemotherapy drug known for its harmful effects on the heart. In a study with 28 male rats, we compared different treatment groups, including those receiving doxorubicin alone and those treated with grape seed extract alongside it.
Our results showed that rats given grape seed extract experienced less heart damage, as indicated by lower levels of injury markers and oxidative stress in their blood and tissue samples. This suggests grape seed extract may potentially help safeguard the heart in chemotherapy settings.
Our results showed that rats given grape seed extract experienced less heart damage, as indicated by lower levels of injury markers and oxidative stress in their blood and tissue samples. This suggests grape seed extract may potentially help safeguard the heart in chemotherapy settings.
Read More
9
We investigated how grape seed extract affects heart function in diabetic conditions by conducting a study on rats. The rats were split into groups, including some that received the extract and others that exercised.
After eight weeks, we found that those who combined grape seed extract with exercise saw improvements in their coronary vascular health. This suggests that using both together could be a cost-effective way to tackle heart complications linked to diabetes. However, we should note that the study was performed on rats, and more research is needed to confirm these findings in humans.
After eight weeks, we found that those who combined grape seed extract with exercise saw improvements in their coronary vascular health. This suggests that using both together could be a cost-effective way to tackle heart complications linked to diabetes. However, we should note that the study was performed on rats, and more research is needed to confirm these findings in humans.
Read More
9
We investigated the impact of grape seed proanthocyanidin extract (GSPE) on heart damage caused by cyclosporine A (CsA), an immunosuppressive drug known for its cardiotoxic effects. In a study involving 24 rats, we measured various markers of oxidative damage after treatment with CsA.
Results showed that while CsA increased oxidative damage, the addition of GSPE significantly reduced this damage and improved overall heart health. Notably, GSPE's antioxidant and antiapoptotic properties were found to play a critical role in protecting heart tissue from CsA-induced harm.
Results showed that while CsA increased oxidative damage, the addition of GSPE significantly reduced this damage and improved overall heart health. Notably, GSPE's antioxidant and antiapoptotic properties were found to play a critical role in protecting heart tissue from CsA-induced harm.
Read More
9
We explored the impact of grape seed extract (GSE) on heart disease in the context of high-fat diet-induced obesity. Using a rat model, we observed that a high-fat diet led to serious heart issues such as inflammation and dysfunction over 45 days. Remarkably, GSE counteracted these harmful effects, highlighting its potential as a protective agent for heart health. However, while these results are promising, it’s essential to understand whether the findings will translate effectively to human health before we draw any definitive conclusions.
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9
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Protects against heart disease
52 people found this helpful
Grape seed extract possesses antioxidant properties superior to other known antioxidants, including vitamins C and E. It protects against heart disease and cancer, enhances vessel condition, safeguards brain cells, and promotes overall vascular health. I always keep this product on hand and use it as a preventive measure for varicose veins. If my review has piqued your interest, please click "YES".
Read More
9
Increases circulation
6 people found this helpful
I have peripheral artery disease due to years of smoking and a sedentary lifestyle. My job involves long hours of sitting, leading to a burning sensation in my thighs. This product has alleviated those symptoms by enhancing my circulation.
Read More
7.5
Supports heart health
3 people found this helpful
Grape seed extract provides various health benefits: it lowers bad cholesterol, prevents cardiovascular disease, and helps maintain endothelial cell function. It's beneficial for diverse groups, including those susceptible to heart disease, high cholesterol, or varicose veins. Please like my comment if you found it helpful.
Read More
9
Supports heart and blood
2 people found this helpful
The grape seed extract is excellent for blood and heart health due to its antioxidant properties. With a serving size of one capsule a day, a package lasts three months. The capsules are small and easy to swallow without any smell or taste.
Read More
9
Improves cholesterol levels
1 people found this helpful
NOW Foods grape seed extract is an exceptional supplement for heart health. After years of taking it, my HDL cholesterol levels are fantastic. This extract effectively neutralises harmful radicals, enhancing overall health. Great product at a reasonable price with high-quality ingredients.
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Frequently Asked Questions
7.5
Supports heart improvement
This extract wonderfully supports the heart, and I have observed improvements while using it.
9
Improves cholesterol levels
1 people found this helpful
NOW Foods grape seed extract is an exceptional supplement for heart health. After years of taking it, my HDL cholesterol levels are fantastic. This extract effectively neutralises harmful radicals, enhancing overall health. Great product at a reasonable price with high-quality ingredients.
7.5
Protects against heart disease
52 people found this helpful
Grape seed extract possesses antioxidant properties superior to other known antioxidants, including vitamins C and E. It protects against heart disease and cancer, enhances vessel condition, safeguards brain cells, and promotes overall vascular health. I always keep this product on hand and use it as a preventive measure for varicose veins. If my review has piqued your interest, please click "YES".
9
Increases circulation
6 people found this helpful
I have peripheral artery disease due to years of smoking and a sedentary lifestyle. My job involves long hours of sitting, leading to a burning sensation in my thighs. This product has alleviated those symptoms by enhancing my circulation.
7.5
Aids heart health
1 people found this helpful
I take CoQ10 for heart health and blood pressure, often alongside omega-3 fish oils, twice daily. This regimen has worked well for me. Over the past two years, I've embraced a lifestyle with more exercise and less animal fats.
7.5
Improves heart condition
4 people found this helpful
The Grape Seed Extract from Now Foods, enriched with vitamin C and calcium, heightens the effect of the active substance. Each capsule contains 100 mg of extract, with a recommendation of two capsules daily. This dietary supplement is ideal for those with cardiovascular diseases and promotes overall body well-being.
9
Supports heart and blood
2 people found this helpful
The grape seed extract is excellent for blood and heart health due to its antioxidant properties. With a serving size of one capsule a day, a package lasts three months. The capsules are small and easy to swallow without any smell or taste.
6
Prevents heart disease
3 people found this helpful
This grape seed supplement not only contains vitamin C and calcium but also offers comprehensive nutritional support. It aids in preventing heart disease, while also providing antioxidant protection for blood vessels and promoting beauty. I take two to three capsules daily.
9
We aimed to explore how grape seed extract can protect the heart from damage caused by doxorubicin, a chemotherapy drug known for its harmful effects on the heart. In a study with 28 male rats, we compared different treatment groups, including those receiving doxorubicin alone and those treated with grape seed extract alongside it.
Our results showed that rats given grape seed extract experienced less heart damage, as indicated by lower levels of injury markers and oxidative stress in their blood and tissue samples. This suggests grape seed extract may potentially help safeguard the heart in chemotherapy settings.
Our results showed that rats given grape seed extract experienced less heart damage, as indicated by lower levels of injury markers and oxidative stress in their blood and tissue samples. This suggests grape seed extract may potentially help safeguard the heart in chemotherapy settings.
8
Grape seed extract benefits heart health
We explored the effects of grape seed extract from Vitis vinifera on heart health in diabetic rats. By giving this extract over 28 days, we aimed to see if it could lessen heart damage caused by diabetes and heart attack.
Our findings showed that the extract successfully reduced oxidative stress and inflammation related to heart injury. While this is promising, the study was conducted on rats, and further research is needed to confirm these benefits in humans.
Our findings showed that the extract successfully reduced oxidative stress and inflammation related to heart injury. While this is promising, the study was conducted on rats, and further research is needed to confirm these benefits in humans.
8
We explored how grape seed proanthocyanidin (GSP) affects heart disease in a study involving rats with monocrotaline-induced pulmonary arterial hypertension (PAH).
After GSP treatment, we saw notable improvements, including lower pulmonary arterial pressure and reduced indicators of vascular stress.
Additionally, GSP seemed to help at the cellular level by enhancing nitric oxide production and reducing inflammation in lung tissue. Overall, this suggests GSP could be a promising candidate for preventing PAH and improving heart health.
After GSP treatment, we saw notable improvements, including lower pulmonary arterial pressure and reduced indicators of vascular stress.
Additionally, GSP seemed to help at the cellular level by enhancing nitric oxide production and reducing inflammation in lung tissue. Overall, this suggests GSP could be a promising candidate for preventing PAH and improving heart health.
References
- Sergazy S, Shulgau Z, Fedotovskikh G, Chulenbayeva L, Nurgozhina A, et al. Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity. Sci Rep. 2020;10:14720. 10.1038/s41598-020-71827-9
- Adıyaman MŞ, Adıyaman ÖA, Dağlı AF, Karahan MZ, Kaya İ, et al. Effects of grapeseed extract on doxorubicin-induced cardiotoxicity in rats. Herz. 2021;46:103. 10.1007/s00059-019-04888-w
- Chen F, Wang H, Zhao J, Yan J, Meng H, et al. Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: in vivo and in vitro studies. J Nutr Biochem. 2019;67:72. 10.1016/j.jnutbio.2019.01.013
- Yang D, Li S, Gao L, Lv Z, Bing Q, et al. Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation. J Nutr Biochem. 2018;62:43. 10.1016/j.jnutbio.2018.07.013
- Tousson E, Elgharabawy RM, Elmasry TA. Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4. Oxid Med Cell Longev. 2018;2018:9434385. 10.1155/2018/9434385
- Nour MS, Sarhan NR, Mazroa SA, Gawish SA. Histological and immunohistochemical study of cardiac telocytes in a rat model of isoproterenol-induced myocardial infarction with a reference to the effect of grape seed extract. Acta Histochem. 2017;119:747. 10.1016/j.acthis.2017.09.007
- Giribabu N, Roslan J, Rekha SS, Salleh N. Methanolic seed extract of Vitis vinifera ameliorates oxidative stress, inflammation and ATPase dysfunction in infarcted and non-infarcted heart of streptozotocin-nicotinamide induced male diabetic rats. Int J Cardiol. 2016;222:850. 10.1016/j.ijcard.2016.07.250
- Luan SS, Yu F, Li BY, Qin RJ, Li XL, et al. Quantitative proteomics study of protective effects of grape seed procyanidin B2 on diabetic cardiomyopathy in db/db mice. Biosci Biotechnol Biochem. 2014;78:1577. 10.1080/09168451.2014.930320
- Badavi M, Abedi HA, Sarkaki AR, Dianat M. Co-administration of Grape Seed Extract and Exercise Training Improves Endothelial Dysfunction of Coronary Vascular Bed of STZ-Induced Diabetic Rats. Iran Red Crescent Med J. 2013;15:e7624. 10.5812/ircmj.7624
- Terauchi M, Horiguchi N, Kajiyama A, Akiyoshi M, Owa Y, et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause. 2014;21:990. 10.1097/GME.0000000000000200
- Ammar el-SM, Said SA, El-Damarawy SL, Suddek GM. Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats. Pharm Biol. 2013;51:339. 10.3109/13880209.2012.729065
- Ozkan G, Ulusoy S, Alkanat M, Orem A, Akcan B, et al. Antiapoptotic and antioxidant effects of GSPE in preventing cyclosporine A-induced cardiotoxicity. Ren Fail. 2012;34:460. 10.3109/0886022X.2012.656563
- Mokni M, Hamlaoui-Guesmi S, Amri M, Marzouki L, Limam F, et al. Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart. Cardiovasc Toxicol. 2012;12:158. 10.1007/s12012-012-9155-1
- Guler A, Sahin MA, Yucel O, Yokusoglu M, Gamsizkan M, et al. Proanthocyanidin prevents myocardial ischemic injury in adult rats. Med Sci Monit. 2011;17:BR326.
- Charradi K, Sebai H, Elkahoui S, Ben Hassine F, Limam F, et al. Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis. Cardiovasc Toxicol. 2011;11:28. 10.1007/s12012-010-9101-z
- Zuo YM, Wang XH, Gao S, Zhang Y. Oligomerized grape seed proanthocyanidins ameliorates isoproterenol-induced cardiac remodeling in rats: role of oxidative stress. Phytother Res. 2011;25:732. 10.1002/ptr.3331
- Guo X, Xiao T, Lin L, Gao Q, Lai B, et al. Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients. Front Immunol. 2024;15:1436747. 10.3389/fimmu.2024.1436747
- Yang Y, Rivera L, Fang S, Cavalier M, Suris A, et al. Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development. iScience. 2024;27:110631. 10.1016/j.isci.2024.110631
- Gajardo Cortez AIJ, Lillo-Moya J, San-Martín-Martinez D, Pozo-Martinez J, Morales P, et al. Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans. Clin Pharmacol Drug Dev. 2024;13:1051. 10.1002/cpdd.1443
- Tánczos B, Vass V, Szabó E, Lovas M, Kattoub RG, et al. Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts. Eur J Pharm Sci. 2024;195:106721. 10.1016/j.ejps.2024.106721
- Üstündağ H, Demir Ö, Huyut MT, Yüce N. Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats. Sci Rep. 2024;14:3098. 10.1038/s41598-024-52932-5
- Kenedy IJ, Kabuhaya JF, Mashauri HL. Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration. Health Sci Rep. 2023;6:e1687. 10.1002/hsr2.1687
- Chang A, Martin KA, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clin Transplant. 2023;37:e15153. 10.1111/ctr.15153
- Manolis AA, Manolis T, Melita H, Manolis AS. Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1. Curr Vasc Pharmacol. 2023;21:378. 10.2174/1570161121666230912155548
- Sato T, Matsumura M, Yamamoto K, Sugizaki Y, Shlofmitz E, et al. A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions. JACC Cardiovasc Interv. 2025;18:622. 10.1016/j.jcin.2024.12.001
- Zaglia T, Campo A, Moro N, Di Mauro V, Borile G, et al. Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt. Proc Natl Acad Sci U S A. 2025;122:e2402639122. 10.1073/pnas.2402639122
- Nerlekar N, Vasanthakumar SA, Whitmore K, Soh CH, Chan J, et al. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial. JAMA. 2025. 10.1001/jama.2025.0584
